Diabytes
2018 World Cup qualifier News
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The November 2016 tie, which will be restaged in November, was won by South Africa 2-1 after Ghanaian referee Joseph Lamptey awarded them a controversial penalty.
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Portugal still harbour hopes of winning the group and qualifying automatically as Cristiano Ronaldo's side host Switzerland in Lisbon next month.
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Italy's first defeat in a qualifier since 2006 means Spain now lead Group G of European qualifying by three points with just three games remaining and can also count on a far superior goal difference.
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Hummels floored the hosts with his goal which left Germany on 21 points at the top of European Group C, five clear of Northern Ireland who won 3-0 in San Marino.
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Bertrand and Welbeck added late goals before Kane sealed his double and his 10th in 20 internationals.
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The result means that Brazil, who became the first South American side to qualify for Russia earlier this year, sit atop the group with 36 points after 15 games, 11 points clear of second-placed Colombia.
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The 32-year-old, Portugal's record scorer, took his haul in the current qualifying campaign to 14 goals in seven games and his overall tally to 78 in 144 international appearances.
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New Paris St Germain signing Kylian Mbappe, who joined the capital club earlier on Thursday, wrapped up the victory in added time after the teenager came on as a late substitute.
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Belgium's victory matched their biggest competitive margin -- a 10-1 mauling of San Marino in a 2002 World Cup qualifier.
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Real Madrid winger Asensio, 21, and Torino striker Belotti, 23, were absent when Italy knocked Spain out of Euro 2016 last year but have since blossomed into two of the most exciting attacking players in Europe.
Two Leigh Griffiths free-kicks left England facing a first qualifying defeat since October 2009, only for Kane to volley in a 93rd-minute leveller from substitute Raheem Sterling`s left-wing cross.
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With Wayne Rooney having again been overlooked, England do not currently have a permanent captain and Southgate said Kane, 23, would wear the armband at Hampden Park.
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Sweden snatched victory with an Ola Toivonen goal from the half-way line in extra time after a poor clearance from France goalkeeper Hugo Lloris.
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Mertens had the visitors ahead just past the half hour mark but there was to be no repeat of the 8-1 hammering that Belgium handed Estonia in Brussels in November.
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Klose now plans to join Germany`s coaching staff after an invitation from head coach Joachim Loew.
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Iker Casillas`s omission from the Spain squad by newly-appointed coach Julen Lopetegui has made Buffon realise he cannot go on forever.
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While Spain put eight unanswered goals past minnows Liechtenstein in their opening Group G qualifier in Leon last month, 10-man Italy returned from Israel with the points from a battling 3-1 win in Haifa.
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Mueller failed to score even once during Germany`s run to the Euro 2016 semi-finals, but the 27-year-old rediscovered his best form in Oslo as he increased his international goals tally to 34.
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Goalkeeper Peter Shilton, capped 125 times, holds the overall record.
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England`s preparations have been affected by the loss of goalkeeper Fraser Forster who injured his arm in training and the withdrawal of left back Luke Shaw, who had returned to train with Manchester United as England look to manage his workload.
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