Delray Beach Open News
He held serve easily throughout and one break in each set was enough, clinching victory when Opelka sent a service return long.
Isner dropped only one point on his first serve and broke his Slovakian opponent three times on the outdoor hardcourt to advance.
Battle-scarred Argentine Juan Martin del Potro clinched his 21st career title with a 6-4 6-4 win over Kevin Anderson in the Mexican Open final in Acapulco on Sunday.
Tiafoe, 20, becomes the youngest American to win an ATP World Tour title since Andy Roddick triumphed at Houston in 2002 as a 19-year-old.
Both Rohan Bopanna and Divij Sharan exited from their respective ATP World Tour events following contrasting defeats.
The 20-year-old American needed four match points to finish off Argentina`s del Potro, the latest seed to fall in a tournament that saw top seed and defending champion Jack Sock, sixth-seeded John Isner and ninth-seeded Milos Raonic beaten on Wednesday.
Towering 20-year-old Opelka, playing in his first ATP level tournament of 2018, fired 17 aces past world number eight Sock to cap a day of upsets.
Veteran Leander Paes and his partner Purav Raja crashed out of the Delray Beach Open after suffering straight-set defeat in the opening round of the men's doubles event, here.
Injuries limited Raonic's time on the court in 2017 and this was just his second tour-level win in six months.
Indian qualifier Ramkumar Ramanathan suffered a tame straight-sets defeat at the hands of American Donald Young to bow out of the Delray Beach Open.
Despite some shaky moments, Raonic fought off a set point in the second-set tiebreaker and closed out the match with his 17th ace of the night to advance to the meeting with Sock, a 6-4, 7-6 (7/2) winner over fellow American Donald Young.
Argentina`s Del Potro, the 2011 Delray Beach champion playing just his second match of 2017, held on to beat the 24-year-old Bosnian 7-6 (7/5), 4-6, 6-3.
Raonic, who reached the tie-breaker with his 11th ace and reached match point with his last ace, booked a Friday quarter-final matchup against British eighth seed Kyle Edmund,
Del Potro, who climbed to number four in the world rankings in 2010, is currently at 1,042nd in the world.
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